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Our surface chemistry uses metal ions in polymeric form to attach proteins to synthetic surfaces via chelation and coordination chemistry. This mechanism allows scientists to immobilise proteins gently onto the surface. This novel approach results in both performance and workflow advantages over the conventional covalent or passive binding chemistries.
Our technology combines the ease-of-handling of passive adsorption with the strength of binding of covalent chemistry. By gently yet strongly binding, our chemistry works better with many proteins that scientists find them challenging with conventional coupling methods. Conventional binding methods can reduce protein activity through irreversible chemical or structural modification.
Our technology relies on avidity binding (multiple weak bonds) to strongly hold proteins in place. Polymeric metal ions form coordinate bonds with electron donating groups of synthetic surfaces on one side and biomolecules on the other.
A single coordination interaction between a metal ion to a synthetic surface or a biomolecule is neither strong, nor irreversible. By using metal ions in a polymeric complex form that utilises multiple, slow exchanging coordination interactions a very strong, yet flexible bond is formed. The activated metal complex surface is stable for long term storage unlike most reactive covalent chemistries that degrade very quickly after chemical activation. Our technology gives the flexibility to either have a ready-to-use activated surface or particle stored for up to 12 months.
A broad variety of synthetic materials and surfaces and formats are used in life sciences, diagnostics and medical devices. All these surfaces have different characteristics, and traditionally require different chemistries and processes for protein attachment.
Anteo has created a surface chemistry platform that works on a broad range of synthetic materials. We have developed products tailored to the following applications:
- Particle Conjugations sizes from 200nm to 3µm and Lateral Flow applications (Click here to view product range)
- Biosensors built on COC, COP and carbon nanotubes (Click here to view product)
- Luminex® Platform (Click here to view product)